Gordon Cook (CTC Chair)
To date, the CTC has held 33 meetings, attended from an invitee list of 86 transplant centre directors, BMT physicians, trainees and scientific staff. The meetings attract an average attendance of 15-20 delegates. The aim of the CTC is the timely completion of conducted studies and publication in peer-reviewed journals to inform and direct clinical BMT practice. Since 2002, 23 retrospective studies have been action by the CTC, 18 of which have been closed and analysed. Median time from download to study distribution: 24 days (4-436) & median time from study distribution to study closure: 166 days (10-586). The time for study download and dissemination to transplant centres is short and becoming shorter. It has been noted that the centre participation is on the whole good and time to study reporting appeared to be shorter than with the EBMT. To improve the process and prioritise workload, several documents have been generated: CTC Authorship Policy, CTC Trial proposal template, CTC Trial proposal Reviewer’s template and CTC Procedural SOP, all available from the website along with CTC Agenda/minutes (http://bsbmt.org/ctc-clinical-trials-committee/).
The main output of the CTC, in terms of publications, has been 23 published manuscripts since 2002. Only 4 of these have been in journals with an impact factor >5, and the current strategy and aims is to improve on the impact of our published work. Currently, the CTC has 4 manuscripts in preparation/submission phase at this time.
At the recent (no. 33) CTC, we considered 8 new studies, 3 potential prospective studies and 5 retrospective studies. There are currently 6 retrospective studies in progress: Retrospective Study: Allo SCT in elderly patients (CTC 06-02) – Cook; Retrospective Study: Outcome of Allo SCT in CML >CP2 (CTC 07-02)– Cook/Marks;
Pulmonary function post-AlloSCT (CTCR 09-01) – Brown; Retrospective comparison of outcome following ATG vs Alemtuzumab conditioning regimens in AlloSCT for SAA (CTCR 09-03) – Marsh; Retrospective analysis of outcomes of RIC AlloSCT for adult ALL (CTCR 10-01) – Peniket/Medd; Retrospective analysis of UK ASCT for autoimmune disorders (CTCR 10-02) – Snowden; Influence of pateint/donor KIR haplotypes on outcomes after MUD AlloSCT for AML (CTCR 10-03) – Schellekens/Marsh. There are currently 8 prospective studies in progress: Transplantation of UBC from MUD in patients with haematological disease using a RIC AlloSCT (CTC 04-02) –Hough [n=5]; UKMF/BSBMT Myeloma X R(Intensive) Study (CTC 05-02) – Cook [n=190]; Prospective Phase II Study: BEAM-Campath RIC Allo for MCL (CTC 07-01) –Rule/Russell; Reduced Intensity Allografting for Chemosensitive Hodgkin lymphoma (ReACH; CTCP 07-03) – Peggs [n=2]; Pilot of AlloSCT in Refractory Disease (PAIReD; CTCP08-01) – Peggs [n=3]; Validation of pre-transplant co-morbidity assessments in the UK (CTCP 09-02) – Moore/Gilleece [n=65]; RIC UBC in patients with haematological malignancy (CTCP 10-01) – Hough; Intracranial haemorrhage in thrombocytopenic haematology patients (InCiTe; CTCP 10-02) – Stanworth.
The work of the CTC represents the best pathway to delineating in-depth analysis of transplant activity in the UK. This in conjunction with the BSBMT Executive Committee strategy for detailed disease-specific outcomes with European benchmarking exercises aims to determine what is best clinical practice in BMT in the UK, and that such standards in practices are internationally equitable.
Gordon Cook
Chair, CTC
Downloads:
SOP for Retrospective BSBMT Registry Studies FINAL -
please see SOP for Retrospective BSBMT Registry Studies
CTC Authorship policy – please see CTC_AUTHORSHIP_POLICY_Jan_09
CTC Study Proposal Template – please see BSBMT_CTC_Study_Proposal_Template
Upcoming BSBMT Clinical Trials Committe Meeting Agendas
Please click below to download the agenda for upcoming meetings
Past BSBMT Clinical Trials Committee Meeting Agendas
Please click below to download the agenda for previous meetings already held
Final Agenda BSBMT CTC 33 4th March 2011
Final Agenda BSBMT CTC 32 25th November 2010
Final Agenda BSBMT CTC 31 18th May 2010
